Hormesis is the name given to the process by which lesser degrees of cellular stress and damage can result in long-term benefits to health. Cells react to molecular damage with greater repair and maintenance activities, and when that damage occurs ... [Continue Reading]
Longevity-Related Genes are Under Greater Evolutionary Constraint in Large and Long-Lived Mammals
Both the evolution of aging and the comparative biology of aging between species with widely divergent lifespans are fascinating topics, though likely of limited relevance to the near future of rejuvenation therapies. Those treatments will be based ... [Continue Reading]
Correction of Mitochondrial Dysfunction as an Approach to Treat Heart Failure
Mitochondria are the power plants of the cell, and when their activity falters, cell and tissue function suffers as a consequence. Unfortunately mitochondrial dysfunction is a feature of aging, and is connected to the progression and severity of ... [Continue Reading]
Reduced Generation of New Oligodendrocytes May Contribute to Declining Memory with Age
A number of the aspects of cognitive decline are connected to loss of stem cell activity with age, and thus reduced numbers of new somatic cells created to carry out functions in the brain. This is certainly the case for memory, but most such ... [Continue Reading]
EnClear Therapies Raises $10 Million to Develop a Means to Filter Molecular Waste from Cerebrospinal Fluid
Leucadia Therapeutics and EnClear Therapies are both testing the hypothesis that clearance of molecular waste from cerebrospinal fluid is a viable form of prevention and treatment for many neurodegenerative conditions, though they couldn't be more ... [Continue Reading]
A Short Review of the Development of Senolytic Therapies to Reverse Aspects of Aging
This short open access review paper covers some of the high points of the past decade of development of senolytic therapies capable of selectively destroying senescent cells in old tissues, as well as some of the earlier, much more sparse work on ... [Continue Reading]
An Approach that Prevents Earlier than Expected Cell Death in Alzheimer’s Disease
Researchers here provide evidence for significant levels of cell death to occur in the brain earlier than expected in the development of Alzheimer's disease, during the stage of mild cognitive impairment thought to be driven by the aggregation of ... [Continue Reading]
An Interview with Lewis Gruber of SIWA Therapeutics
SIWA Therapeutics is one of the few senolytics biotech companies founded prior to the past few years, invigorated with new funding now that the clearance of senescent cells as a basis for rejuvenation is an area of intense interest for the research ... [Continue Reading]
A Comparison of Biological Age Measurement Approaches
Researchers here assess the performance of a range of approaches to measuring biological age, including a number of epigenetic clocks based on DNA methylation changes characteristic of aging. The ideal measurement of biological age is one that is ... [Continue Reading]
An Interview with Hanadie Yousef of Juvena Therapeutics
The Life Extension Advocacy Foundation volunteers here interview Hanadie Yousef of Juvena Therapeutics. Her team is mining the secretions of pluripotent stem cells to find factors that can improve regeneration and stem cell activity in older ... [Continue Reading]
Transplantation of Young Bone Marrow into Old Mice Produces Systemic Benefits
Researchers here report that transplanting bone marrow from young donor mice into old recipient mice produces a range of benefits, such as improvement in the behavior of macrophage cells. Bone marrow stem cells are responsible for producing blood and ... [Continue Reading]
Transplantation of Senescent Cells is an Issue in First Generation Stem Cell Therapies
Researchers here demonstrate that comparatively simple regenerative cell therapies, of the sort presently widely used, in which stem cells are derived from adipose tissue, will tend to introduce senescent cells into the recipient in the case of older ... [Continue Reading]
Deacetylation of the NLRP3 Inflammasome as a Way to Control Chronic Inflammation
Chronic inflammation is an important component of degenerative aging. Excessive inflammatory signaling and activation of the immune system arises due to a combination of many factors, of which some are more important than others, such as the presence ... [Continue Reading]
Aspects of Immune System Aging Proceed More Rapidly in Men
Men do not live as long as women. This is a consistent effect across populations and eras, and there are any number of theories as to why this is the case. This might lead us to expect measurable aspects of aging to be more pronounced in older males ... [Continue Reading]
Evidence for Loss of Capillary Density to be Important in Heart Disease
Loss of capillary density, and thus flow of blood through tissues, is a known feature of aging, though the causes of this change in tissue maintenance are far from completely explored. It is proposed to be quite important in loss of tissue function, ... [Continue Reading]
The Aging Retina, a Mirror of the Aging Brain
Retinal degeneration is a feature of old age, and here researchers show that it correlates quite well with a loss of volume in portions of the visual cortex of the aging brain. These two portions of the nervous system are are connected and related, ... [Continue Reading]
Evidence for PASK Deficiency to Reduce the Impact of Aging in Mice
There are many ways to slow aging to a measurable degree in short-lived species such as mice, and the work noted here is a recently discovered example. Mice have evolved to have a sizable variability of life span in response to environmental ... [Continue Reading]
The Potential for Exosome Therapies to Treat Sarcopenia
The authors of this open access review walk through some of the evidence for delivery of exosomes, such as those derived from stem cells, to be a basis for treating sarcopenia. Sarcopenia is the progressive loss of muscle mass and strength that takes ... [Continue Reading]
Exceptionally Long Lived Humans Exhibit Slower Epigenetic Aging, Measured by DNA Methlyation Clocks
Epigenetic clocks are produced by examining age-related changes in DNA methylation, finding combinations of such changes that are consistent across populations, and predict chronological age. These clocks also predict mortality, in the sense that ... [Continue Reading]
Reviewing Efforts to Develop NAD+ Therapies to Reverse Age-Related Loss of Mitochondrial Function
Increasing levels of NAD+ in mitochondria, is a class of therapy that probably produces most of its benefits in animal models and human trials by restoring mitophagy. This may well be true of mitochondrially targeted antioxidants as well. Mitophagy ... [Continue Reading]
Endothelial Cell Senescence can Impair Insulin Sensitivity
The growing presence of senescent cells contributes to near all of the declines and tissue dysfunctions of aging, judging by the results produced in extensive research carried out in animal models of age-related disease. Senescent cells secrete a mix ... [Continue Reading]
A Mechanism by which Chronic Inflammation Spurs Cancer Metastasis
Chronic inflammation is a risk factor for cancer and cancer mortality. There are numerous reasons as to why this might be the case, some much more proven and settled than others, but the research here is focused on metastasis, the spread of cancerous ... [Continue Reading]