Klotho is one of the few robustly demonstrated longevity-associated genes. Greater expression extends life in mice, while reduced expression shortens life. Present investigations of the mechanisms by which klotho produces effects on life span are ... [Continue Reading]
Old Hematopoietic Stem Cells Transplanted into Young Bone Marrow Do Not Regain Function
Epigenetic modifications to DNA, gene expression, and cell function all change for the worse in stem cells in old tissues. Researchers here show that putting old hematopoietic stem cells into a young tissue environment acts to reverse many of these ... [Continue Reading]
Screening for Existing Drugs Capable of Enhancing the Mitochondrial Unfolded Protein Response
The growing interest in manipulating aspects of metabolism related to aging is still largely focused on the range of cell maintenance mechanisms that are triggered into greater operation by calorie restriction and other stresses. Efforts are underway ... [Continue Reading]