A fair amount of effort is presently put towards the exploration of supplements derived from vitamin B3 compounds (nicotinamide, niacin, nicotinamide riboside) that act as precursors to enable the manufacture of nicotinamide adenine dinucleotide ... [Continue Reading]
Visceral Fat Behaves Differently in Long-Lived Dwarf Mice
A few varieties of dwarf mice exhibit considerable longevity. They are produced via forms of mutation that disable portions of growth hormone metabolism, such as via growth hormone receptor knockout. Most research has thus focused on insulin ... [Continue Reading]
Further Evidence for Exercise to Improve Memory via Increased Blood Flow
To what degree is increased blood flow to the brain the important mechanism mediating the beneficial effects of exercise on memory? Exercise improves memory both in the very short term, and over the long term. This may be as simple as increased blood ... [Continue Reading]
Greater Exercise Correlates with Improved Functional Connectivity in the Aging Brain
Researchers here investigate detailed measures of brain function over time, and correlate them with the level of physical activity. There is plenty of evidence for greater physical activity to slow cognitive decline with age and reduce the risk of ... [Continue Reading]
Somatic Chromosomal Mosaicism as a Mechanism of Aging and Disease
Stochastic mutational damage to nuclear DNA occurs constantly in the body, and near all of it is quickly repaired. Most unrepaired damage occurs in DNA that isn't used, or the change has only has a small effect on cell metabolism, or occurs in a ... [Continue Reading]
Age-Impaired Autophagy Makes CD4+ T Cells Inflammatory
Here, researchers discuss data that sheds light on the way in which age-related declines in autophagy, related mitochondrial dysfunction due to impairment of mitochondrial autophagy, and decline of the immune system might interact with one another. ... [Continue Reading]
Is Ageism a Useful Explanation for Lack of Progress Towards Rejuvenation Therapies?
While ageism certainly exists, I've never really liked the use of ageism as an explanation for the lack of progress towards rejuvenation therapies, and this in an era of biotechnology in which all the fundamental puzzle pieces exist and just need to ... [Continue Reading]
Loss of NAD+ Implicated in Age-Related Circadian Rhythm Dysfunction
As for other aspects of metabolic regulation, circadian rhythm becomes increasingly disrupted with age. Researchers here provide evidence for falling NAD+ levels to be a proximate cause of this issue. NAD+ is important in the core activity of ... [Continue Reading]
Kingsley Advani on Investing in the Longevity Industry
Kingsley Advani is one of the more active angel investors in the growing longevity industry. This is still a young industry, and like many of people involved, whether as entrepreneurs or investors, Advani is motivated more by an interest in achieving ... [Continue Reading]
Certain p53 Sequence Changes are Indicative of Species Longevity
Scientists here expand upon prior research indicating that longer-lived species tend to exhibit certain types of sequence difference in the tumor suppressor gene p53 - a gene also involved in many other processes relevant to aging. One might compare ... [Continue Reading]
Exercise Acts Through Wnt Signaling to Slow Brain Aging in Rats
Researchers here report on the application of various forms of exercise program to aged rats, followed by observing the effects on age-related cognitive impairment and related changes in the biochemistry of the brain. Wnt signaling, connected to a ... [Continue Reading]
Jim Mellon Funds Aging Research at University of Oxford
Jim Mellon is doing a fair amount to help push the research and medical communities towards the development of therapies to slow and reverse the progression of aging. He is quite vocal in the business community, and is one of the founders of ... [Continue Reading]
Mechanisms of Calorie Restriction and Intermittent Fasting
This open access paper provides a good high-level overview of what is known of the molecular mechanisms underpinning the beneficial response to calorie restriction and intermittent fasting. In short-lived species, quite sizable gains in life span are ... [Continue Reading]
Alk Inhibitors to Slow Aging
A number of receptor tyrosine kinases are implicated in areas of metabolism known to influence the pace of aging in short-lived laboratory species. Researchers here investigate Alk, a receptor tyrosine kinase previously understudied in this context. ... [Continue Reading]
Early Life Epigenetic Changes can Set the Stage for Later Life Metabolic Dysfunction
Epigenetic markers on DNA determine the pace and timing of protein production, and are thus one of the important influences on cell and tissue function. Cells adjust their epigenetic programs in response to the surrounding environment, but ... [Continue Reading]
Failing Mitophagy in the Progression of Aging
Mitochondria, the power plants of the cell, decline in function with age. This contributes to the development of age-related conditions, particularly in energy-hungry tissues such as muscle and brain. An important proximate cause of this failure is ... [Continue Reading]
Ten Weeks of Resistance Training in 60-Year-Olds Doubles NAD+ Levels in Muscle Tissue
When looking at any of the work presently taking place on improving metabolism in older individuals, whether by stress response upregulation, or by improving mitochondrial function, it is always worth checking the human data, where it exists, to ... [Continue Reading]
Plasma from Young Rats Reduces Epigenetic Age Measures and Senescent Cell Burden in Old Rats
This study is interesting on a few counts. Firstly, transfusion of old individuals with plasma from young individuals has failed to produce usefully large benefits in human trials, and the evidence in mice looks similarly shaky. Yet here, in rats, ... [Continue Reading]
SENS Research Foundation on COVID-19 and Aging
SENS Research Foundation here explains why COVID-19, like near all infectious disease, is far worse for the old. It isn't just a matter of the decline of immune function, though that is the bulk of it. Older people have a greater burden of damage and ... [Continue Reading]
Correlating Structural Changes in the Hippocampus with Memory Decline
Memory function declines with age. Some part of this is the result of outright structural damage in the brain, caused by the periodic rupture of small blood vessels that kills a small volume of tissue - a form of damage that proceeds that much more ... [Continue Reading]
MiR-375 and Autophagy in the Progression of Osteoarthritis
Much of the work that the research community conducts on age-related disease is similar to the example here: attempting to pick apart the proximate causes of pathology in an altered, aged, diseased cellular metabolism. This is far removed from root ... [Continue Reading]
Improving Transplanted Stem Cell Function via Tethered Signal Molecules
The field of biotechnology is churns with inventive technology demonstrations; this is an era of creativity, unleashed by a rapid advance in knowledge and capabilities. Here, researchers are presented with the challenge of achieving sustained ... [Continue Reading]