Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested ... [Continue Reading]
New Research: Superior Weight Loss Results With Isagenix
Trainer: Eric Gumpricht, Ph.D., Director of Research & Science Director of Research & Science, Dr. Eric Gumpricht, breaks down the impressive results from our latest clinical weight loss study to be published in a top, peer-reviewed ... [Continue Reading]
Knowing Both a Great Deal and Too Little About the Mechanisms of Sarcopenia
Today's open access paper is a tour of the better known mechanisms of post-translational modification of proteins, and their relevance to the universal age-related loss of muscle mass and strength, the onset of sarcopenia. It is a good example of the ... [Continue Reading]
Measures of Biological Age Largely Correlate with Cancer Risk
Cancer is an age-related condition. With age, there is a greater background of mutational damage that spreads throughout tissues. Greater inflammatory, pro-growth signaling by lingering senescent cells makes the environment more hospitable for ... [Continue Reading]
The New Alzheimer’s Therapies are Not What One Would Call Successful
The first batch of immunotherapies demonstrated to be capable of clearing extracellular amyloid-β from the brain have performed poorly in late stage Alzheimer's patients. Data is beginning to emerge for their ability to modestly slow down the ... [Continue Reading]
Barriers to full benefit of AI for older adults
One of the media-fueled risks today with the plethora of AI-related hype is the tendency to find and publicize deficiencies and mistakes, reinforcing the premise that it is too early for benefits across industries like senior living or home care. ... [Continue Reading]
Jump Into Action For Bone Health
More than 43 million adults are affected by low bone mass, a risk factor for developing osteoporosis or suffering fractured bones later in life. Twice as many women are affected by low bone mass and osteoporosis combined as men (1). Nutrition is part ... [Continue Reading]
Targeting Mitochondrial Oxidative Stress
Cells are each packed with hundreds of the organelles called mitochondria, the distant descendants of ancient symbiotic bacteria, constantly dividing, fusing, and passing around component parts. Mitochondria are the power plants of the cell, ... [Continue Reading]
The Relationship Between Telomere Length and Replicative Senescence is Quite Different in Blind Mole Rats
In mammalian tissues, cells become senescent constantly as a result of reaching the Hayflick limit on cell replication. Telomeres, lengths of repeated DNA sequences at the ends of chromosomes, are reduced in length with each cell division. When too ... [Continue Reading]
Proposing a Model for the Epigenetic Contribution to Aging
Is epigenetic change a cause or consequence of aging, and are epigenetic clocks measuring a cause or consequence of aging? In today's open access preprint, researchers build a model of the epigenetic contribution to aging, and propose that the answer ... [Continue Reading]
Fight Aging! Newsletter, May 8th 2023
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested ... [Continue Reading]
Osteopontin is Involved in Macrophage Senescence in Aging Fat Tissue
Visceral fat tissue generates inflammation through a range of mechanisms, and this only becomes worse with advancing age. The more visceral fat tissue, the worse the long-term consequences for metabolism, driven by inflammatory signaling. One of ... [Continue Reading]
Protein Aggregation in the Aging Heart
As noted in this open access paper, protein misfolding and aggregation is a body-wide feature of aging, not only associated with the brain and neurodegenerative conditions. In the case of the heart, it is becoming apparent that misfolding of ... [Continue Reading]
What Can I Have on a Shake Day?
Trainer: Mona Dolgov, Nutritionist, Cookbook Author, & Culinary Expert With the 30-Day Reset, you’re set for a month of Shake Days and Cleanse Days. But what other food can you have on Shake Days? Isagenix keeps meal and snack planning ... [Continue Reading]
On the Optimization of Exercise for Long Term Health and Longevity
How much optimization of exercise is a reasonable goal, given what is presently known? Today's open access paper makes the fair point that our hunter-gatherer evolution matches us to a certain strategy, meaning a lot of moderate exercise leavened ... [Continue Reading]
The AI opportunity – more and better services
Wondering if there's any news about AI? Just from yesterday, May 3, 2023 – that list goes on and on. MIT Technology Review packs all the AI news that’s fit to pack into an up-to-the-minute digest. The New York Times attempts similar for the ... [Continue Reading]
On the Aging of Microglia
Microglia are innate immune cells of the brain. They are analogous to macrophages elsewhere in the body, responsible for clearing up debris, destroying pathogens and problem cells, and participating in regeneration. They also undertake an arguably ... [Continue Reading]