The future of cancer therapy, and ultimately an end to cancer, will be built atop mechanisms that are as close to universal as possible, such as inhibition of telomere lengthening, or that are relevant to a large fraction of cancers, such as the ... [Continue Reading]
The Interaction of Senescent Cells and Macrophages in Fibrosis
The interaction between senescent cells and macrophages is of great importance to wound healing. Differences in the behavior of these two cell types appear critical to proficient regeneration in species like salamanders versus poor regeneration and ... [Continue Reading]
Delivery of α-klotho as a Basis for Neuroprotective Treatments
Klotho is one of the few well-established longevity-associated genes that works in both directions in animal models: less klotho shortens life span, while more klotho extends life. Klotho also improves cognitive function. The mechanisms by which ... [Continue Reading]
Age-Related Hearing Impairment Correlates with Age-Related Physical Impairment
It should not be surprising to find correlations between manifestations of age-related degeneration, even those in which it is debatable as to whether age-related condition A can contribute meaningfully to the progression of age-related condition B, ... [Continue Reading]